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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Quantification of STAT3 in mastectomized tissues of Iraqi women with breast cancer

Author: ALAA OBAID, MOHAMMED JABER MHAWISH , MUSA NIMA MEZHER
Abstract: Signal transducer and activator of transcription 3 (STAT3) is abnormally activated in various cancer types, included with40% and more of breast cancers in contrast to accuratelyregulatedSTAT3 as a latent protein factor in normal mammary cells, this study aims to determine the signal transduction and activator of transcription factor ( STAT3) activity and expression level in human breast cancer involving RT-qPCR technique and performed at Al-Sader teaching hospital in the province of Al-Najaf – Iraq in which carried out on 52 formalin fixed and paraffinized breast tissue samples, of them 32 malignant, 10 benign breast lesions and 10 healthy normal mammary tissues as the control .Real time qPCR technique was applied onbreast tumor tissues and controls.The present research was found a statistical significance as value of P = 0.01 in quantification of STAT3 between malignant and benign breast tissues compared with those of normal in which reflect the level of STAT3 activity and expression as in normal tissue were stable while in malignant ones exhibited substantial heterogenicity between minimal and maximal values of real time PCR cycle threshold with no evidence of significant association in STAT3 activity in relation with clinicopathological characteristics of breast cancer .In conclusion: A high significantly relationship with STAT3 expression and activation and quantification of STAT3 between malignant and benign breast tissues compared with those of normal in which reflect the level of STAT3 activity and expression as in normal tissue were stable while in malignant ones exhibited substantial differences between minimal and maximal values in which STAT3 quantification were abnormal in breast malignant tissues .
Keyword: STAT3 ,mastectomized tissues, Iraqi women ,breast cancer
DOI: https://doi.org/10.31838/ijpr/2020.12.03.211
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