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Study of androgen receptor as a quadruple marker in breast carcinoma
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| Author:
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TYAGI KISHOR, PRACHI PALSODKAR, PRACHI PALSODKAR, VAGHA SUNIT, HIWALE KISHORE MADHAVRAO
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| Abstract:
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Background: Breast carcinoma is second largest cause of tumor/cancer in the world. Breast carcinoma can be de?ned according to absence/presence of expression of oestrogen, progesterone & HER-2 receptor. Absence of all of three receptor called as Triple negative breast carcinoma (TNBC). Four main TNBC subtypes have been de?ned, Basal 1 & 2, LAR (Luminal androgen receptor) & Mesenchymal. Luminal androgen receptor depends on Androgen Receptor signaling pathway and most sensitive to AR-antagonists. Androgen receptors plays crucial role in the treatment of Carcinoma Breast, mostly used in Tamoxifen resistant and Triple negative breast carcinoma are Androgen Receptor Antagonist
Objectives: Compare of AR status with ER,PR, and Her2.
Methodology: Slide of newly diagnosed patients of breast carcinoma stained by H and E stain and immunohistochemical stain(ER,PR,Her2,AR) will be studied.
Results: Result would be undertaken in spss softwere.
Conclusion: The conclusion will be based on findings of the study of protocol.
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| Keyword:
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Carcinoma Breast, ER, AR, PR, HER2, TNBC, Breast carcinoma Progesterone receptor, Estrogen receptor, Human epidermal growth receptor 2, Triple negative breast carcinoma
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.01.208
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| Download:
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Request For Article
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