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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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A Study on Analgesic Efficacy of Intrathecal Bupivacaine and Fentanyl with Intrathecal Midazolam for Lower Limb Surgeries.

Author: DEEPJIT BHUYAN, ARUNA V. CHANDAK, AMOL SINGAM, S.S. CHAUDHARI
Abstract: Background: Subarachnoid block is considered a safe regional anaesthesia technique. This technique is widely used for both elective as well as emergency surgical procedures. It is a good anaesthesia technique for surgeries like caesarean section, lower abdominal surgeries, lower limb orthopaedic surgeries and urological procedures. Objectives: To evaluate the efficacy of intrathecal midazolam in potentiating the analgesic effect of intrathecal fentanyl along with a prolonged sensorimotor block in patients undergoing lower limb surgery. Methodology: The present study is carried out in the Department of Anesthesiology, JNMC & Acharya Vinoba Bhave Rural Hospital, Sawangi (Meghe), Wardha after taking prior permission from institutional ethical committee. Randomized, prospective, case-controlled study. This study will comprise of 100 patients. They will be randomly allocated into two groups of 50 each. Group F (50 subjects) – intrathecally 3 ml of 15mg 0.5% hyperbaric bupivacaine + 25 mcg of fentanyl in 0.5 ml along with 0.2 ml 0.9% saline and Group M (50 subjects) – intrathecally 3 ml of 15 mg 0.5% hyperbaric bupivacaine + 25 mcg of fentanyl in 0.5 ml along with 1 mg of midazolam in 0.2 ml. Results: We hypothesize that intrathecal midazolam would potentiate the effect of intrathecal fentanyl in terms of prolonged duration of analgesia and prolonged sensory and motor block without any significant hemodynamic compromise. Conclusion: When the result will come as expected then we can conclude that concept incorporating intrathecal midazolam and fentanyl together for a prolonged duration of analgesia and prolonged sensory and motor block without any significant hemodynamic compromise.
Keyword: intrathecal, fentanyl, midazolam, analgesia, efficacy
DOI: https://doi.org/10.31838/ijpr/2019.11.04.511
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