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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Comparative Evaluation of The Effect of Clonidine And Dexmedetomidine As Adjuncts To Lignocaine In Intravenous Regional Anaesthesia In Forearm And Hand Surgeries.

Author: KRISHNENDU S, ARUNA V CHANDAK, AMOL SINGAM, A.R. NARKHEDE
Abstract: Background: Biers block which is also known as IVRA Intravenous Regional block, is for short procedures of extrimities. It is reliable and considered as safe and it has faster onset of analgesic action, but major disadvantage is tourniquet pain and post-operative analgesia will be less. Drugs like dexmedetomidine and clonidine which are a2 agonist has shown to enhance the blockade of peripheral nerve (4). The main aim of this study is to compare clonidine and dexmedetomidine as adjuvants to intravenous regional anaesthesia to study the block characteristics, analgesia post-operative and pain to tourniquet application Objectives: To compare and study the analgesia duration when clonidine and dexmedetomidine added as adjuvant to I.V 0.5% lignocaine (preservative free) in IVRA. Methodology: A prospective, observational study conducted on 70 adult patients who will be divided into two group 35 of each group. Group A -Clonidine 1 mcg/kg , Group B- Dexmedetomidine 1 mcg/kg will be added to 40 ml 0.5% lignocaine(lignocaine free). Result: We hypothesis that with dexmedetomidine onset of sensory -motor block will be faster and recovery will be significantly delayed compared to clonidine. It is also shown that Dexmedetomidine shows longer duration of analgesia. Conclusions: When the result will come as expected then we can conclude that concept of dexmedetomidine onset of sensory and motor block will be faster and recovery will be significantly delayed compared to clonidine. And also that Dexmedetomidine shows longer duration of analgesia.
Keyword: Dexmedetomidine, Clonidine, Lignocaine, IVRA, Biers block
DOI: https://doi.org/10.31838/ijpr/2019.11.04.514
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