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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Evaluation of Serum Ferritin Level in Anaemic & Nonanemic Pregnant Women & Its Correlation with Maternal and Perinatal Outcome

Author: POOJA KSHIRSAGAR, AMARDEEP TEMBHARE, PRACHI PALSODKAR
Abstract: Background: In pregnancy anaemia is described as concentration of haemoglobin below 11 g / dL and low ferritin is described as serum ferritin levels less than 12 mg / L. At term pregnant women's haemoglobin and ferritin concentration are estimated to determine their values and assess their effect on maternal & perinatal outcomes. Methods: Concentration of Haemoglobin and levels of serum ferritin of 600 pregnant women will be estimated. Out of which 300 selected are anaemic and remaining 300 are non-anaemic according to selection criteria. They all are receiving 5 mg of folic acid daily till first trimester and 200 mg of elemental iron from second trimester. When patient comes at the time of labor, 2.5ml of blood will be collected from every patient into EDTA bulbs for CBC analysis and another 2.5mL into plain bulbs for serum ferritin levels by using standard solid phase direct sandwich ELISA method (Enzyme Linked Immuno-Sorbent Assay) with VITROS 5600 machine. Results: Haemoglobin and Serum ferritin will be studied in both groups, and levels will be compared in anaemic & non anaemic groups. Along with this comparison of serum ferritin levels in mild, moderate, severe and very severe anaemia will be done. Maternal outcome & fetal outcome according to the haemoglobin and serum ferritin values will be discussed. Conclusion: The timely accurate diagnosis of anaemia will help mothers to prevent the poor maternal & perinatal outcome. In huamn the body iron stores exist mainly in the form of ferritin. The concentration of serum ferritin is positively correlated with the total body iron stores in the absence of inflammation. The measurement of plasma ferritin (serum ferritin) level has the highest specificity and sensitivity for detection of iron deficiency in anaemic mothers. In this study, correlation of low levels of serum ferritin with maternal and perinatal outcome will be studied.
Keyword: haemoglobin, ferritin concentration, pregnant women
DOI: https://doi.org/10.31838/ijpr/2019.11.04.515
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