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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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An Indirect Titrimetric Method for the Determination of Platyphylline Hydrotartrate Using Potassium Hydrogen Peroxomonosulfate

Author: NIKOLAY BOYKO, MYKOLA YE. BLAZHEYEVSKIY, VALERIY V. MOROZ, ELENA T. ZHILYAKOVA, ANASTASIYA Y. MALYUTINA
Abstract: Aim: To investigate a possibility of application of KHSO5 as a reagent in the oxidimetric determination of platyphylline hydrotartrate. Materials and methods: Platyphylline hydrotartrate was determined by indirect titration with KHSO5. The required amount of platyphylline hydrotartrate was dissolved in water, pH buffer solution (?? 8.5-9.2), and KHSO5 solution was added. In 3-5 min, the solution was acidified. The excess of KHSO5 was iodometry titrated applying visual end-point detection. Results: The results of the quantitative determination of PT in a solution for injection of 2 mg•ml-1, tablets 0.005 g and 0.5 % ophthalmic solution prepared ex tempore showed satisfactory precision and accuracy: RSD= 1.68%, [(? ¯- µ) 100% / µ] < RSD. The recovery of this analyte in the preparation sample ranged from 99.5 to 105 %. Conclusions: The advantages of the applied analytical techniques in the determination of platyphylline hydrotartrate in pharmaceutical preparations have been presented. The applied technique was very simple, convenient, accurate, precise, and economical.
Keyword: kinetics; oxidation; platyphylline hydrotartrate; analysis; oxone
DOI: https://doi.org/10.31838/ijpr/2020.12.02.201
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