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Evaluating the Effectiveness of Pharmacological Correction of Experimental Hyperlipidemia with a Combination of L-Ethoxidol and Rosuvastatin
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| Author:
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ELENA ZAKHAROVA, ANNA P. VASILEVA, PAVEL D. KOLESNICHENKO, KONSTANTIN M. REZNIKOV, IRINA A. POPOVA
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| Abstract:
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Aim of the study: Study of hypolipidemic properties of a combination of L-ethoxidol and rosuvastatin on a model of experimental hyperlipidemia.
Materials and methods: Hyperlipidemia was modeled on 70 mature male Wistar rats by intragastric probe introduction of an oil suspension of cholesterol at a dose of 50 mg/kg daily for 40 days until the total cholesterol dose of 2000 mg/kg was reached, as well as a single intraperitoneal introduction of Twin-80 at a dose of 250 mg/100g on the 40th day. Then the animals were divided into groups and for 14 days received a course of treatment with L-ethoxidol, rosuvastatin, as well as a combination of these drugs, against the background of continued introduction of cholesterol. On the 14th day from the start of treatment, as well as on the 28th day, blood was taken from the retroorbital sinus and the lipid profile in the blood serum was evaluated.
Results: On the model of long-term hyperlipidemia, it was found that the combination of the antioxidant L-ethoxidol and a hypolipidemic drugrosuvastatin did not show a significant effect of lowering total cholesterol, compared to the group of rosuvastatin monotherapy and is comparable with the results of this group on day 14, but after the withdrawal of rosuvastatin to use of L-ethoxidol reduced cholesterol levels.
Conclusion: The addition of L-ethoxidol does not increase the anti-cholesterol effect of rosuvastatin, but it promotes its prolongation.
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| Keyword:
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hyperlipidemia, hypercholesterolemia, endothelial dysfunction, rosuvastatin, L-ethoxidol, metabolic syndrome.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.02.207
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| Download:
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