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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Morphological features of the elements of the knee joint on the background of the hypofunction of the thyroid gland

Author: BAHRINISO ESHONKULOVA, UTKIR MIRSHARAPOV, HAMIDULLA RASULOV, QAMBARALI SHERALIEV
Abstract: This article is devoted to the urgent problem of studying the importance of hypothyroidism in the deformation of the musculoskeletal system, in particular the knee joint in childhood. Analysis of the obtained data shows degenerative - dystrophic changes in the hyaline cartilage of the joint surface of the tibia and condyle of the femur expressed by vacuolization of the cytoplasm, most chondrocytes, necrobiosis and necrosis. In the metaphysical zone of both bones, individual newly formed bone beams and cavities filled with fatty bone marrow are revealed. The relief of the ossification line has a wavy trajectory. All this is characteristic of the inferior development of bone-cartilage structures of the knee joint. Histological and histochemical studies revealed significant dystrophic changes in the joint capsule, synovial membrane of the round ligament, leading to underdevelopment of the elements of the knee joint. A characteristic feature of the synovial membrane is diffuse detection of mucoid substances, both in the main substance and in the cytoplasm of fibroblasts. Conducted comprehensive morphological, histological and histochemical studies allow us to characterize the earliest changes in the elements of the knee joint during hypothyroidism, which, apparently, is associated with metabolic disorders and is the cause of pathological development.
Keyword: knee joint; synovial membrane hypothyroidism; dystrophy; necrosis; hyaline cartilage; mucoid substances; joint capsule; osteo-cartilaginous; chondrocytes.
DOI: https://doi.org/10.31838/ijpr/2020.12.03.250
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