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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Diagnostics of cerebrocardiac syndrome in the acute period of subarachnoidal hemorrhage in neurologic reanimation

Author: V.G. IGNATYEVY, T.R. POSKACHINA, T.S. DYAGILEVA, D.N. SEMENOV
Abstract: Cerebrocardiac syndrome (CCS) is characterized by changes in the electrocardiogram (ECG) in various lesions of the brain. In the acute period of subarachnoid hemorrhage (SAH) differential diagnosis of acute coronary syndrome (ACS) and neurogenic myocardial injury is an urgent problem. A retrospective study was conducted to study the frequency of electrocardiographic changes in the CCS in the acute period of the SAH. 91 patients with SAH in acute period were examined. 63.7 % of detected aneurysms of cerebral vessels, 4.4 % – arterio-venous malformation. CCS was diagnosed in 24.2% of cases and was accompanied by various deviations of t-wave, ST-segment, appearance of pathological Q-wave in two or more leads on the electrocardiogram. These changes in ECG were associated with a violation of the local contractility of the left ventricle myocardium (p=0,015; or = 6,2; 95% CI:1,2–35,1). There is no Association of ECG changes with gender sign (p=0.813). Changes in ECG were associated with massive hemorrhage with fatal outcome (p=0.001 (OR=5.3).; 95% CI:1,8–16,1)), which indicates the determinant role of Central nervous system pathology in the CCS pathogenesis.
Keyword: subarachnoid hemorrhage, aneurysm, cerebrocardiac syndrome, acute coronary syndrome
DOI: https://doi.org/10.31838/ijpr/2020.12.03.255
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