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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Effect of Phenols Extracted from Linumusitatissimum (flax) Seeds on Growth of in Vitro Leishmaniatropica Promastigotes

Author: MAKSOOD MAHMOUD
Abstract: In the present study, the phenolic compounds from Linumusitatissimum (flax) seeds were in vitro extracted, isolated, and used as antileishmanial agents. The isolated fractions that contained phenols were detected by the HPLC technique and tested against the Leishmaniatropica promastigotes parasite. It was found that the studied phenols have remarkably inhibited the parasite’s growth; the 50% inhibitory concentration of the promastigotes (IC50) at the log phase of 96 hr was 50 µg phenols/ 1 ml culture. Furthermore, the extracted phenols decreased the number of generation and increased time of generation comparing with the control group. It can be concluded that the phenols show a promising antileishmanial approach and may have a potential role in finding novel antileishmanial drugs. These results were obtained as the phenolic compounds could affect the metabolism of proteins, nucleic acids, and energy of the parasite.
Keyword: Lieshmaniatropica, Linumusitatissimum (flax), Quercetine, Catchine, Keampferol, Rutin.
DOI: https://doi.org/10.31838/ijpr/2020.12.02.243
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