IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Left Ventricle Mechanics Evaluation by Four-Dimensional Speckle Tracking in Children with Uncorrected Patent Ductus Arteriosus

Author: ASAAD NOAMAN, FALAH MAHDI DANANAH, AMINA A.B. AL-DEJELI
Abstract: Children suffering from patent ductus arteriosus (PDA) are at high cardiovascular risk in childhood and adulthood. Although there were many studies on left ventricle (LV) function in PDA children, not study was reported using Four-dimensional (4D) echocardiographic speckle tracking (ST) analysis in uncorrected rather than post ligation patients. This work aimed at evaluating LV mechanics of the global longitudinal strain (GLS), the global circumferential strain (GCS) and global radial strain (GRS) in children with uncorrected PDA in comparison with a healthy control people. Sixty-two people (25 with PDA and 37 normal) were involved. Their mean age was 11.52±2.5 months (54% male), and 11.1±2.07 (41% male). All participants were subjected to the clinical evaluation and echocardiographic examination. LV function was also assessed by two-dimensional (2D) ejection fraction (EF), fractional shortening (FS) and 4D echocardiography speckle tracking (STE). Longitudinal and circumferential Myocardial deformation in those with PDA were documented less than in the healthy children while 4D radial strain, 2D EF and FS were higher in PDA patients. For PDA and control groups, GLS was -17.404±1.06 versus -20.66±1.6 (P: 0.000) respectively and the GCS was-17.87±0.62 for PDA patients in contrast to -21.36±1.57 (P: 0.000) for the control groups. The GRS of PDA was +46.5±6.3 while the normal group was +38.26±3.01 (P: 0.000). 2D EF 74.47±3.6 was for the patients with PDA while 72.7±2.9 (P: 0.04) was for the normal ones. The PDA and control groups were 2D FS 37.49±1.7 versus 36.38±1.8 (P: 0.02). A new technique by 4D derived ST showed that children with uncorrected PDA were subjected to early subclinical LV mechanical insults despite the apparently normal or augmented LV systolic function which necessitates early intervention to avoid these consequences.
Keyword: Four-dimensional Echocardiography, Speckle Tracking, Left Ventricle Mechanics, Patent Ductus Arteriosus.
DOI: https://doi.org/10.31838/ijpr/2020.12.02.248
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free