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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Estimation and comparison of serum calcium, serum uric acid and C-RP in preeclamptic and normal pregnant women in Dhiraj General Hospital of sumandeep Vidyapeeth Vadodara: A case sectional study

Author: DR SHAH, MRS DRASHTI BHRAMBHATT
Abstract: Preeclampsia is one of the major conditions causing maternal morbidity and mortality throughout the world. Hyperuricemia due to oxidative stress is known to be associated with deleterious effects on endothelial function, oxidative metabolism, platelet adhesiveness and aggregation. C-reactive protein (CRP) is an acute phase reactant protein, plays a role in eliciting the inflammatory response characteristic of preeclampsia. Patients with Preeclampsia showed the low levels of serum calcium. To estimate serum uric acid, CRP and serum calcium in cases and controls and to study the association of the levels of serum uric acid, CRP and calcium with preeclampsia. A case control study conducted on 100 patients with clinically diagnosed preeclampsia and 100 normotensive singleton pregnant women as controls from the general population from Dhiraj General Hospital, Piparia, Vadodara, Gujarat. 6 ml of each venous blood was collected to estimate the Serum Uric Acid, CRP and Serum Calcium levels in subject. The data was analyzed and expressed in terms of mean ± SD. There was statistically significant increase in the levels of serum uric acid, CRP (P < 0.001) and statistically decreased levels of serum calcium (P < 0.001) in cases as compared to the normal controls. It can be concluded that serum uric acid, CRP and serum calcium could be considered as a supportive diagnostic tool in preeclampsia.
Keyword: Preeclampsia; Serum Uric Acid; CRP; Serum Calcium; Oxidative stress; Endothelial injury.
DOI: https://doi.org/10.31838/ijpr/2019.11.03.167
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