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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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THE ROLE OF KISSPEPTIN / KISS 1R IN ENDOMETRIAL IMPLANTATION IN PATIENT WITH ASSISTED REPRODUCTIVE TECHNOLOGY

Author: ARIE POLIM, NUSRATUDDIN ABDULLAH, ROSDIANA NATZIR, MOH. HATTA, HULDANI, HARUN ACHMAD, BAYU INDRA SUKMANA
Abstract: We conducted a review of literatures regarding the role of kisspeptin in endometrial implantation in patients with assisted reproductive technology. Study results showed kisspeptin has an important role. Of several types of kisspetin, kisspeptin-10 as physiological activator of KISS1R in the human placenta, plays the most important role in humans. Kisspentin also regulates in development process of stromal cell decidualization so as to increase adhesion and implantationaofatheablastocystain theaendometriumaand deficiency of plasma cispeptin on the day of the HCG tiggered will reduce the embryo implantation possibility. In Kisspeptin IVF position also can reduce the level of vascular permeability and VEGF thereby reducing the risk of the occurrence of OHSS due to the process of gonadotrophin stimulation.
Keyword: kisspeptin, endometrial implantation, assisted reproductive technology
DOI: https://doi.org/10.31838/ijpr/2020.12.03.319
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