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Effect of new synthesized compounds of 2-Thiouracil Sulfonamide Derivatives against colon and liver carcinoma cells “In Vitro Study"
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| Author:
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SAIF M.HASSAN, ASHWAQ NAJEMALDEEN ABBAS AL-JAF, YASMEEN ALI HUSSIEN, SAMIR M.AWAD, MAYSAA ALI ABDULKHALEQ, NAJAH R.HADI
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| Abstract:
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Many studies have been focusedon 2-Thiouracil derivatives as an anti-cancer therapy. The target compounds were prepared to be tested on colon and liver carcinoma cells and compared them with 5-FU. The newly synthesized compounds were showed variable effectiveness against colon cancer; however, the most active compounds were carbothioamides7a and 7c which showed high activity against both types of cell lines. Moreover, the 4a-c, 5a-c, and 6a-c compounds were showed ineffectiveness against liver cancer while other compounds were showed cytotoxic activity more than 5-FU especially 7a, 7c, and 3a, we are recommended that need to study the toxicity effect of these effective compounds and tested them in vivo.
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| Keyword:
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synthesized compounds, Thiouracil Sulfonamide, colon, liver carcinoma cells
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.286
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| Download:
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