*Five Years Citation in Google scholar (2016 - 2020) is. 1451*   *    IJPR IS INDEXED IN ELSEVIER EMBASE & EBSCO *       

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
An in Silico Approach To Identify The Potential Protein Targets Of Luteolin In Common Dental Pathogens

Author: SHREYA KOTHARI, J.VIJAYASHREE PRIYADHARSINI, SMILINE GIRIJA A.S
Abstract: The study aims to demonstrate the antimicrobial activity of luteolin against common dental pathogens using an in silico approach. Luteolin is a flavonoid rich in antioxidant, anticancer, anti allergic, and antihypertensive properties. Dental caries is one of the most common infectious diseases in humans. Periodontal disease is an inflammatory disorder manifested in periodontium mainly caused by P.gingivalis. Luteolin contains antifungal, anti influenza, anti malarial properties. The software used were STITCH for interaction of Luteolin with the proteome of bacteria, VICMPred for identification of functional class of proteins, VirulentPred for identification of virulence properties of proteins, BepiPred v2.0 for identification of epitopes on the virulent protein, PSORTb v3.0 –for identification of the subcellular location of the virulent protein. This approach gave a result at the molecular level and with its subcellular location, epitope and finding the virulence factor, luteolin was proved to be useful as an antimicrobial agent to eradicate dental pathogens.
Keyword: Luteolin, P.gingivalis, STITCH,VirulentPred.VICMPred
DOI: https://doi.org/10.31838/ijpr/2020.12.03.335
Download: Request For Article
 




ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free