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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Correlation Polymorphism of PTPN22 Gene with Systemic Lupus Erythematosus Disease in Southern Iraq

Author: GHANEEMAH HAMADI, DR. MANAL BADI SALEH
Abstract: SLE (Systemic lupus erythematosus) is an autoimmune inflammatory disorder causing Self-endurance loss with hyper activation of self-reactive B and T cells. PTPN22 (protein tyrosine phosphatase non-receptor type 22) encodes for LYP (lymphatic phosphatase) and it a central passive regulator for T lymphocyte activation. Recent studies have shown the link among gene of PTPN22 variants + 1858C > T and multiple autoimmune diseases. Present research was aimed for investigating the relationship among PTPN22 gene polymorphisms and SLE in southern Iraq. Present research involved 110 SLE patients and 70 as control group from healthy volunteers. Extracted genomic DNA and genotyping was done using (P C R – R F L P) polymerase chain reaction –restriction fragment length polymorphism method. The 1858 T allele frequency showed association (O R = 0.26, CI 95% = 0.14 to 0.48, p < 0.001 with SLE patients relative to control group. In conclusion. The frequency recorded in this analysis of PTPN22 R620W gene functional variable is among the highest in comparison With the other inhabitants of the world, the widespread prevalence of this variable in patients with SLE as compared to controls indicates its important contribution along with other factors to the conferral of SLE susceptibility. The frequency of 1858 T demonstrated a correlation allele in patients with SLE compared to control group in study population. Our study illustrated that there was no correlation between Genotype, Gender` and` Risks of SLE. There was, however a substantial correlation between Age` and Risks of SLE.
Keyword: PTPN22 Gene, Single Nucleotide Polymorphism, Genetic Variants, SLE.
DOI: https://doi.org/10.31838/ijpr/2020.12.03.370
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