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Formulation and In Vitro Evaluation of Bioadhesive Tablets Using Hydrophilic Gum Blends
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| Author:
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UPLOADED BY-ADMIN, V. N. DESHMUKH, A.A. HARSULKAR, D. M.SAKARKAR
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| Abstract:
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Controlled release matrix tablets of theophylline were designed with hydrophilic gum blends
as a bioadhesive polymer. Combinations of natural hydrophilic polymers such as Xanthan gum and
Locust bean gum were used in different concentrations to formulate bioadhesieve tablets. Tablets of
theophylline were prepared by direct compression method and were subjected to in vitro bioadhesion
strength and in vitro drug dissolution for 12h by using USP dissolution apparatus basket type at speed
of 100rpm at a temperature of 37 ± 0.5°C using simulated gastric fluid (pH 1.2). The bioadhesive
strength of the tablets was measured as force of detachment against porcine gastric mucosa. The in
vitro release study as well as retention time of bioadhesive tablets on mucous membrane were investigated
to develop a bioadhesive polymer based controlled release delivery system and to evaluate the
performance of such delivery device. Combination of xanthan gum: locust bean gum (4:6) in concentration
of 1:0.5 (drug: gum) showed significant bio-adhesive strength and were dissolved in the gastric
fluid with maximum release of 96.95% in 12h. Increase in gums concentration increases the drug release
profile as well as bio-adhesive strength of tablets.
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| Keyword:
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Theophylline, Xanthun gum, Locust bean gum, Controlled release
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| EOI:
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| DOI:
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