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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Status of some selected Trace Elements Levels and lipid profile in Ischemic heart disease patients with type 2 Diabetes Mellitus

Author: , ABD ELGADIR A.ALTOUM, HANI M. MOHAMED, AHMED L. OSMAN, MARWAN ISMAIL, PRAVEEN KUMAR KANDAKURTI, ASAAD MA. BABKER
Abstract: Objective: This aimed to evaluate the levels of serum chromium, zinc, lipid profile and glycosylated hemoglobin HB A1c in Sudanese with type 2 diabetic patients and also to association the relation of these elements with some Diabetes Ischemic heart disease ( IHD ) patients . Subjects and Methods: A cross sectional study,case control conducted during the period from March 2014 to September 2015 to evaluation Trace elements status and it is association with Ischemic heart disease ( IHD ) in Sudanese with type 2 Diabetes Mellitus compared to healthy volunteers. Three hundred of diabetic patients who attended from Khartoum, Omdurman and Khartoum North hospitals in Khartoum state, Sudan, for routine follow up and a control group of 100 healthy subjects (non-diabetic). About 7 milliliters of venous Blood specimens were collected from both groups, and serum levels of serum levels of lipid profile , chromium , zinc in and glycated hemoglobin (HbA1c) were determined . For statistical analyses, Student’s t-test and the ODD ratio were used. Results: clinical characteristics were not statistically different between the groups in terms of age, sex. Also, statistically different between the groups in terms of weight and BMI. The results of the study indicate a significant raised in the means of the serum levels of cholesterol, LDL, triglyceride, and HbA1c of the test group when compared with healthy control group subjects, whereas the means of the serum levels of HDL , chromium and zinc showed significant reduction when compared with that of control group. also in this study there is significant between the means of the serum level of blood triglyceride, cholesterol, LDL of the diabetic patients with ischemic heart disease and those without ischemic heart disease, also there is significant decrease in the men of serum levels of chromium , zinc of the patients with ischemic heart disease and those without this disease. , also there is no significant in the men of serum levels of HDL , HbA1c of the patients with ischemic heart disease and those without this disease. The results of current study indicate moderate significant positive correlation between the duration of disease (in years) and the serum triglyceride, cholesterol, LDL and HBA1c and show significant moderate negative correlation with serum levels of HDL ,chromium and zinc , also indicate significant strong positive correlation between HbA1c , triglyceride and cholesterol and significant negative correlation between HbA1c , chromium and zinc whereas there is negative correlation between HbA1c and serum levels of HDL also there is positive correlation between HbA1c and LDL. Also in this study indicate significant strong positive correlation between BMI, HbA1c ,triglyceride and cholesterol and significant negative correlation between, chromium and zinc whereas there is positive correlation between BMI and serum levels of LDL and HDL. Conclusions: Serum Trace elements status was associated with Ischemic heart disease ( IHD ) in Sudanese with type 2 Diabetes Mellitus. The Zn/Cr ratio, in addition to the individual serum levels of trace elements, is important for metabolism in humans.
Keyword: Trace Elements, Ischemic heart disease, Type 2 Diabetes Mellitus
DOI: https://doi.org/10.31838/ijpr/2020.12.04.414
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