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Evaluation of the effect of 1% Metformin Gel coating on the osseointegration achieved around dental implants using bone mineral density and radiofrequency analysis- A clinical and three-dimensional radiographic study.
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| Author:
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HIMANI SHARMA, ANAMIKA SHARMA, SWATI GUPTA, APOORVA MOWAR, CHANDAN KUSUM
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| Abstract:
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Background: Achievement and maintenance of osseointegration is the prime requisite for the long term success of dental implant in the oral cavity. Various measures have been described in literature to coat the dental implant with a bio-stimulant for achieving adequate and rapid osseointegration. The purpose of present case series was to clinically and radiographically assess the osseointegration around dental implants coated with 1% Metformin gel, in terms of bone mineral density and radiofrequency analysis.
Methods: A total of 22 subjects with missing tooth in the mandibular posterior region were selected and divided into two groups for the study; test group (implants coated with 1% metformin gel prior to their placement) and control group (non-coated dental implants). Along with bone mineral density (BMD) in hounsfield units (HU) and radiofrequency analysis (RFA); clinical parameters including oral hygiene index- simplified (OHI-S), gingival bleeding index (GBI), modified plaque index (mPI), modified gingival index(mGI), modified sulcular bleeding index(mSBI), width of keratinized mucosa (WKM), probing depth(PD) were recorded at baseline 4 months and all the implants were revaluated at 24 months.
Results: There was a statistically significant increase in the mean bone mineral densities at the test area at 4 months (1330.1±21.6HU) when compared to control group. Also, the mean ISQ value for both the groups increased significantly during the course of 4 months.
Conclusions: The coating of Metformin on implants has a positive bio-stimulatory effect on osseointegration achieved by them. In the present study this effect was found to be significant for shorter interval (4 months).
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| Keyword:
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Metformin, bone mineral density, osseointegration, Cone beam computed tomography, Implant stability quotient, radio frequency analysis
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.055
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| Download:
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