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Comparative Evaluation of Total and Free Sialic Acid in Saliva of Smokers and Tobacco Chewers to Determine Sialic Acid as A Salivary Biomarker for Oral Cancer
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| Author:
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JOHN FRANCIS, DR.J.SELVARAJ, DR.V.VISHNU PRIYA, DR.R.GAYATHRI
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| Abstract:
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Tobacco chewing is one of the known risk factors for oral cancer and it is widely consumed by residents of India. The present study was aimed at assessing the free and total sialic acid in the saliva and compared among smokers and tobacco chewers. In order to quantify the total and free sialic acid concentration in saliva, A total of 20 patients (n=20) were selected from the department of oral medicine and radiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, and divided two different groups. Group-I served as smokers while Group-II served as tobacco chewers. The sialic acid concentrations were measured by standard biochemical methods and data obtained were statistically analyzed using spectrophotometer. Results of the present study showed that the total sialic acid concentration was found to be higher in the tobacco chewers (14.78?1.20 mg/dl) compared to smokers (9.23?0.56 mg/dl). Similarly, free sialic acid concentration was also significantly higher in the tobacco chewers (25.25?1.82mg/dl) than smokers (16.65?1.37). In both the groups studied, the free sialic acid concentration was higher in tobacco chewers (Group-II) than the total free sialic acid (Group-I). Our present finding indicates that the free sialic and total sialic acid levels are higher in group B (Tobacco Chewers) than group A (Smokers). Our present findings clearly show that salivary total and free sialic acid levels were significantly higher in the tobacco chewers when compared to the people who are having smoking habits which could be due to the carcinogenic effect of smokeless tobacco (Tobacco chewers). It is concluded from the present findings that measurement of total and free sialic acid in saliva may be useful in early detection of oral cancer progression.
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| Keyword:
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Saliva, Total sialic acid, Free sialic acid, Tobacco chewers, Smokers, Oral cancer
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.01.362
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| Download:
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