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Lymphatic Targeted Drug Delivery Systems And Its Application To HIV Treatment; A Review
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| Author:
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JUNA BRIGIT CHACKO, G.R.VIJAYA SANKARA
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| Abstract:
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Human immunodeficiency virus (HIV) infection commonly results in a myriad of comorbid conditions secondary to immune deficiency. Almost nearly 99% of all viral replication occurs in activated and productively infected CD4+ T-cells of the blood and lymphoid tissues. Researchers confirmed that HIV patients on current oral antiretroviral therapy (ART) had lower intracellular drug concentrations in lymph nodes than in blood. For instance, in the same patient, multiple lymph node drug concentrations were as much as 99 % lower than in blood and the insufficient drug level has been linked to viral persistence. We posit that one means to improve these disease outcomes is through the lymphatic targeted drug delivery system. The review discusses the mechanism of lymphatic transport of stable nano-drug formulations such as nanostructured lipid carriers, liposomes, solid lipid nanoparticles, polymeric nanoparticles and various physicochemical properties of the system can be harnessed to best yield lymphatic targeted delivery systems. When completely developed, such targeted delivery platforms have the potential to clear reservoirs of viral infection.
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| Keyword:
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HIV; lymphatic drug delivery; colloidal carrier; passive and active targeting
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.085
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| Download:
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Request For Article
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