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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Inhibition of Osteoporosis by Endophytes – A Computational Approach

Author: DR.S.DAISYLIN ANBU SUJITHA, CHELLAM JAYNTHY
Abstract: Introduction: Bone degenerative disorder results in osteoporosis unless being taken care of in the initial stage. Also, osteoporosis is a silent disease that will be observed only when the fragile bones undergo a fracture or a hairline crack. Drugs given for treating the disease often have side effects. Hence, alternative measures are searched for. Medicinal plants are exploited for their therapeutic applications. Objective: The present work analyzes the osteoporotic potential of the endophyte Alangiumsalvi folium using computational methods. Methods: The interactions of the components of endophytes with the target protein are studied using Discovery Studio 2.0. Pharmacophore analysis is also done. Results: The interaction of the two components kaempferol and quercetin with the target protein has been analyzed using computational methods. Also, kaempferol shows more stable interaction with the target protein. Conclusion: The compound kaempferol is expected to have more potential as an anti-osteoporotic behavior than quercetin.
Keyword: osteoporosis, endophytes, secondary metabolites, docking, Pharmacophores, computational analysis.
DOI: https://doi.org/10.31838/ijpr/2021.13.01.143
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