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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Thyroid Hormones Profile In Patients with Alopecia Areata, A Single Center Study

Author: , MOHAMMAD SHAHATHA NAYAF, AHMED ABDUL-AZIZ AHMED, HAYDER SAAD AHMED , WISAM SUHAIL NAJEM
Abstract: Background: Alopecia areata (in French, pelade) is a non-scaring patchy loss of hair commonly affecting the scalp or any hairy area of the body. According to literatures, thyroid hormonal abnormalities were reported in 8-28% of AA patients. Objective: To evaluate serum T3, T4 and TSH level in patients with AA, and verify any association between the pattern AA and thyroid dysfunction. Patients And Methods: This is a comparative study conducted at Tikrit Teaching Hospital from October 2018 to the end of April 2019. One hundred participant were divided into two groups; 50 patients with AA and 50 age and sex-coordinated healthy controls. The extent and activity of AA were recorded. Evaluation of T3, T4, and TSH for both patients and controls group was done. Informed consent was taken from all participants. Results: In patients group, 24 (48%) were males and 26 (52%) were females while control group included 21 (42%) males and 29 (58%) females. Regarding the pattern of AA, 11 (22%) patients had unilocular AA, 23 (46%) patients had multilocularis AA, 10 (20%) had alopecia totalis, and 6 (12%) had alopecia universalis. Abnormal TSH level was observed in 9 (18%) patients and in 5 (10%) controls, (p<0.211 ) ; abnormal T3 level was observed in 17 (34%) and 7 (14%) among patients and controls group, respectively,(p=0.001); and abnormal T4 level was observed more in patients group 12(24%) than in control group 5(10%), (p=0.211). The level of TSH was abnormal in (77.78%) of the multilocularis type of AA (p=0.047) but only in 22.2% of other AA patterns. Conclusions: Abnormalities in T3 level occur in almost one third of patients with AA. Moreover, the multilocularis type of AA is an indicator of abnormal TSH level.
Keyword: Alopecia areata (AA); thyroid dysfunction; thyroid-stimulating hormone (TSH).
DOI: https://doi.org/10.31838/ijpr/2021.13.01.153
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