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Effect of storage condition on the physicochemical properties of ibuprofen
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| Author:
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GHAIDAA S.HAMEED, MASAR BASIM MOHSIN MOHAMED, YUSRA ABDULGHAFOOR MOHAMMED
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| Abstract:
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In this piece of work we shed the light on the storage of the most popular analgesic among (NSAID); Ibuprofen (apifen®) 200 mg that used widely in the Iraqi market. Patients used this OTC drug without prescription from the pharmacy so that they might not have enough information about its storage. Iraq has a sunny hot weather, so that the patients might not have an idea about the danger of that condition on the drug activity. Patients might store the drug in the fridge because they thought that it is the right place for storage. Other might put the sheet inside the car especially patients who travel for a long time. Some patients might store the drug without a package in the room under the effect of direct light. In this experiment many apifen® tablets where stored at different expected storgae condition’s include: refrigerator, sun light, room temperature and car. All the sored and controlled tablets were subjected to the tablet evaluations test to evaluate their activity according to the formal tests for tablets dosage form. These test are hardness, friability, disintegration, dissolution, thickness and organoleptic property. All the stored tablets showed a change in the evaluation test after 8 weeks storage. These changes might be critical for the bioavailability of apifen® tablets. This type of study is important to the pharmacist in the community pharmacy and inside the hospital. In addition the drug companies will focus by this study a proper packaging of the tablets to ensure its stability after shipping.
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| Keyword:
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Storage, Friability, Degradation
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.02.410
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| Download:
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