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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis of Some Azetidinone Derivatives Containing Ciprofloxacin Moiety

Author: FADHIL D.KHALID, AYAD S.HAMAD, RABIHA H.SALEH, MAHA M.SALIH
Abstract: Thiocarbodihydrazide was synthesized via the reaction between carbon disulfide and hydrazine hydrate using reflux method. Ciprofloxacin was reacted with Thiocarbodihydrazide to synthesize compound [A1] which contains 1,2,4-triazole moiety. Compound [A1] was allowed to react with different aromatic aldehydes ; (4-hyderoxy, 3-hydroxy, 4-chloro, 4-Bromo, 4- (N, N)-Di methyl amino and 4-methoxy) benzaldehyde, this reaction gave the Corresponding schiff bases derivatives [A2-A7]. Azetidinone derivatives [A8-A13) were synthesized via the reaction of compounds [A2-A7] with chloroacetyl chloride in presence of triethylamine as a base. structures of the synthesized compounds were confirmed by melting points, FTI'R, 1H-NMR and 13C-.NMR techniques.
Keyword: Schiff bases; Azetidinone; Ciprofloxacin.
DOI: https://doi.org/10.31838/ijpr/2021.13.01.295
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