|
Serum Hepcidin And Ferritin Level Changes In Iraqi Adult Patients With Non-Transfusion Dependent Beta-Thalassemia Major And Intermedia
|
|
| Author:
|
EHAM AMER ALI, ALI ABDULATEAF ALBAYATI, SAHAR ABDULWAHAB ALSHABAN, KHITAM ALI ALTHAMER
|
| Abstract:
|
Background and objectives: Non-transfusion dependent thalassemia (NTDT) characterized by an increase iron overload with end-organ damage as a consequence. The aim of the current study is to determine the correlation between factors that control and reflect excess iron, (serum hepcidin and ferritin levels), in Iraqi adult patients with non-transfusion dependent Beta-thalassemia major and intermedia. Measurement of these biochemical changes could assist clinical monitoring and advances the understanding of the mechanisms of disease.
Patients and Methods: The current study investigated 84 adult male randomly selected from patients registered at The National Center of hematology with age range(25-65 years) divided into 3 groups: (Group 1 TM) 28 patients with beta-thalassemia major, (Group 2 TI) 28 with beta-thalassemia intermedia, and 28 healthy adult as control (Group 3). The serum hepcidin, ferritin levels and hemoglobin (Hb) of the three groups were measured.
Results: Receiver Operation Characteristic curve (ROC curve) was used and results revealed that the Hb was the more accurate marker (Sensitivity=100% and specificity 100%). A statistically significant differences in means was observed between Hb, serum hepcidin, ferritin and hepcidin/ferritin ratio in all of the three groups (Control, TI & TM), P value <0.0001. Furthermore, in both (TI & TM) groups a strong negative correlation was observed between ferritin and Hepcidin in TI group (Pearson Correlation -.545-**, P =0.003) and in TM group (-.505-**, P =.006). Also a strong correlation was observed in both groups in Hepcidin & hepcidin/ferritin ratio; in TI group (0.796**, P <0.0001) and in TM group (0.606**, P =.001).
Conclusions: being thalassemia phenotype associated with both defective erythropoeitic activities and increase in iron stores. Significant differences were observed comparing control and diseased subjects. Hb, hepcidin and hepcidin/ferritin ratio were significantly higher in control compared to both diseased groups. Serum ferritin was obviously higher in Beta thalassemia patients denoting to iron overload.
|
| Keyword:
|
hepcidin, ferritin, non-transfusion-dependent Beta-thalassemia
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2021.13.01.301
|
| Download:
|
Request For Article
|
|
|