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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Serum Hepcidin And Ferritin Level Changes In Iraqi Adult Patients With Non-Transfusion Dependent Beta-Thalassemia Major And Intermedia

Author: EHAM AMER ALI, ALI ABDULATEAF ALBAYATI, SAHAR ABDULWAHAB ALSHABAN, KHITAM ALI ALTHAMER
Abstract: Background and objectives: Non-transfusion dependent thalassemia (NTDT) characterized by an increase iron overload with end-organ damage as a consequence. The aim of the current study is to determine the correlation between factors that control and reflect excess iron, (serum hepcidin and ferritin levels), in Iraqi adult patients with non-transfusion dependent Beta-thalassemia major and intermedia. Measurement of these biochemical changes could assist clinical monitoring and advances the understanding of the mechanisms of disease. Patients and Methods: The current study investigated 84 adult male randomly selected from patients registered at The National Center of hematology with age range(25-65 years) divided into 3 groups: (Group 1 TM) 28 patients with beta-thalassemia major, (Group 2 TI) 28 with beta-thalassemia intermedia, and 28 healthy adult as control (Group 3). The serum hepcidin, ferritin levels and hemoglobin (Hb) of the three groups were measured. Results: Receiver Operation Characteristic curve (ROC curve) was used and results revealed that the Hb was the more accurate marker (Sensitivity=100% and specificity 100%). A statistically significant differences in means was observed between Hb, serum hepcidin, ferritin and hepcidin/ferritin ratio in all of the three groups (Control, TI & TM), P value <0.0001. Furthermore, in both (TI & TM) groups a strong negative correlation was observed between ferritin and Hepcidin in TI group (Pearson Correlation -.545-**, P =0.003) and in TM group (-.505-**, P =.006). Also a strong correlation was observed in both groups in Hepcidin & hepcidin/ferritin ratio; in TI group (0.796**, P <0.0001) and in TM group (0.606**, P =.001). Conclusions: being thalassemia phenotype associated with both defective erythropoeitic activities and increase in iron stores. Significant differences were observed comparing control and diseased subjects. Hb, hepcidin and hepcidin/ferritin ratio were significantly higher in control compared to both diseased groups. Serum ferritin was obviously higher in Beta thalassemia patients denoting to iron overload.
Keyword: hepcidin, ferritin, non-transfusion-dependent Beta-thalassemia
DOI: https://doi.org/10.31838/ijpr/2021.13.01.301
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