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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Myristica Fragrans seeds extract mitigate non-motor behavioural deficits and oxidative stress in Rotenone model of Parkinson’s disease

Author: MUTHUVEL VIJAYAN KANAGASABAPATHY, SUMANA RADHAKRISHNAN, PRABHU K, RAJASANKAR SRINIVASAGAM
Abstract: Parkinson's disease (PD) is a multi-layered neurodegenerative ailment with cumulative loss of dopaminergic neurons over the limbic areas and nigro-striatal pathways. PD mainly affects the motor behavior of old aged population. Oxidative stress, mitochondrial dysfunction, accumulation of a- synuclein and neuro inflammation was the probable mechanism behind PD pathogenesis. In spite of various understandings, till now effective treatment is unfilled. In PD, both motor signs (tremor, rigidity, akinesia & postural imbalance) and non-motor (NM) symptoms (depression, anhedonia, autonomic dysfunction ) were observed . NM deficits mainly affect the quality of life of PD patients. Rotenone and MPTP are the most widely used lipophilic neurotoxins (cross the blood brain barrier) for evaluating the neuro-protective potential of various compounds and drugs against PD. Nutmeg, an aromatic spice possess various pharmacological properties such as anti-diabetic, anti-epileptic, memory enhancer , aphrosidiac, anti-cancer. Rotenone was injected to male Wistar albino rats by intra-peritoneal route (2.5mg/kg daily) for 30days. In our previous study, we indicated that MFSE extract ameliorated motor, memory deficits in rotenone induced PD model. Current study focuses on Myristica fragrans seed (MFSE) extract against rotenone induced non-motor behavioural deficits and biochemical parameters. In PD NM models, forced swim test (FST) and sucrose intake test (SIT) were conducted to access the depressive behaviour, anhedonia. Oxidative stress were studied by biochemical parameters (lipid peroxidase TBARS, catalase, superoxide dismutase and glutathione peroxidase). MFSE extract (oral) treated groups displayed steady increase in climbing behaviour, low immobility time in FST and elevated percentage of sucrose intake in SIT. It might be due to its neuro-protective, anti-depressant properties.
Keyword: Nutmeg, Myristica fragrans , Rotenone, Parkinson’s disease, Neuroprotection, Anti-depressant
DOI: https://doi.org/10.31838/ijpr/2021.13.01.152
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