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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Diuretic effect of aqueous extracts of Vitex agnus castus leaves and seeds in Wistar Albinos rats

Author: FATIMA EL KAMARI, HASSAN LAAROUSSI, DRISS OUSAAID, YASSINE EL ATKI, AMAL TAROQ, IMANE AOUAM , BADIAA LYOUSSI, ABDELFATTAH ABDELLAOUI
Abstract: Diuretics drugs preserve renal homeostasis. However, conventional currently used diuretics like furosemide induces dysfunction of the renal system. Thus, natural products could be a good alternative with no side effects. Plants contain a cocktail of bioactive compounds, which have potent biological activities such as ameliorating renal disturbance. The present work aimed to evaluate the diuretic ability of extracts of Vitex agnus castus (VAC) in animal model (rats). Single and repeated doses were tested. Urine volume and urine electrolyte excretion increased significantly after the single dose of two studied extracts. No significant change in plasma electrolytes induced by single dose. Whilst, the daily dose of extracts for sixteen days increased urine volume and urinary levels of sodium and potassium but did not cause hypokalemia, whereas the reference drug furosemide increased urinary sodium and potassium and caused hypokalemia. Creatinine clearance was significantly increased by both extracts. Leaves and seeds of Vitex agnus castus have a potent diuretic effect on the rat. However, additional studies are required to identify the active compounds for this effect and explore the mechanism of action.
Keyword: : Vitex agnus castus, Urine volume, Sodium, Potassium, furosemide.
DOI: https://doi.org/10.31838/ijpr/2021.13.01.167
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