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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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HPMC Polymeric System: Structural Contribution in Controlling Drug Release in Sustained Drug Delivery System

Author: AJIT KULKARNI, VIPUL DHASADE, VIVEK INGALE, AMIT KASABE, ARCHANA YADAV, SANTOSH FATTEPUR, NAGARAJA SREEHARSHA, E.BHAVYA
Abstract: There are numerous commercially available cellulosic controlled release ethers that find applications in multiple industries; Hydroxy Propyl Methyl Cellulose (HPMC) is more commonly used to regulate active pharmacokinetics and pharmacodynamics parameters. Various physico-chemical properties of polymers with release rate retardation indicate an effect on the dissolution of a controlled release tablet. Extensive literature indicates that the primary factor influencing the release of the drug was the hydroxypropyl material. In deciding the grade of HPMC polymers, the number of monomers also plays a significant role and influences drug release. When in contact with water, HPMC swells and contributes to drastic shifts in the concentration of polymers and medications and increases the scale of the dosage type. The embedded drug dissolves and diffuses as time passes. The rate of release or breakdown is dependent on the length of the chain and the degree of HPMC substitution used. The major rate release controlling mechanisms are absorption, swelling and erosion. This analysis focuses on numerous factors that influence the release of the drug, including structural characteristics.
Keyword: Controlled release, Hydroxy Propyl Methyl Cellulose, Polymeric structure
DOI: https://doi.org/10.31838/ijpr/2021.13.01.325
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