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Drug-Induced Acute Pancreatitis
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| Author:
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ANURAG LAVEKAR, UMESH MARAPPA, SWARALI TADWALKAR, VIVEK CHAUDHARI
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| Abstract:
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Background
Drug-induced acute pancreatitis (DIAP) is a rare cause of acute pancreatitis. More than 100 drugs have been implicated as the cause of acute pancreatitis and different mechanisms of injury have been proposed. Even though the incidence is not well defined, it has been identified that the onset of drug-induced pancreatitis is closely associated with the intake of newly introduced drugs.
Aim
To describe presentation, toxicity and mortality among acute pancreatitis patients on a wide range of drugs
Methods
An observational study was carried out at the Department of Clinical Pharmacology and Toxicology, JSS Hospital, Mysore, India for a period of one year, Jan-19 to Dec-19. The study included 50 patients. Patients with DIAP were thoroughly validated using anamnestic, clinical or laboratory data. Drug exposure was obtained in a face-to-face interview. Possible drug aetiology was assessed in individual patients through a standardised causality assessment applying the criteria of the World Health Organization. Patients were assessed for response to different therapy regimens and mortality.
Results
There were 31 male patients and 19 female patients. The study showed male preponderance. The mean age of the patients was 40.22±2.20 years. The study identified that the majority of the patients suffered from pancreatitis due to INH / R drug. The incidence of mortality among the patients was negligible in the current study.
Conclusion
In light of the current findings, it was identified that drug-induced pancreatitis is becoming more prevalent in the growing era of newly developed drugs. The diagnosis seems to be underestimated because of the difficulties in determining the causative agent and the need for a retrospective re-evaluation of the suspected causative factors.
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| Keyword:
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Pancreatitis, drug induced, etiolog
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.128
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| Download:
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