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Niosomes: A Targeted Drug Delivery System Overview
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| Author:
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SHUMAILA KHAN, DR. SUSHMA VERMA
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| Abstract:
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Niosomes are synthetic vesicle prepared from non-ionic surfactant and hydrating mixture of cholesterol. Its infrastructure consists of hydrophilic, amphiphilic and lipophilic moieties which accommodate large number of drug molecules with broad range of solubilities. It is preferred over liposome because of the greater stability, low cost, easy storage of non-ionic surfactant than phospholipid. Surfactants do not need any specific condition for handling and storage. It can be administered through oral, parenteral, ocular, transdermal, vaginal, inhalational route which is used as carrier for hormones, synthetic and herbal drug. Niosomes acts as controlled and targeted drug delivery system which reduces toxicity and enhances drug penetration into target tissue. Niosomal drug delivery system acts as localised drug action at the target site based on their size and it also have low penetrability across connective and epithelium tissue. The following review is focused on the various concepts with niosomal, formulation aspects related to its advantages and disadvantages, factor that affect the non-ionic surfactants, different route of administration and correlation with liposomal formulation, the preparation and the characteristics of niosomes along with the recent application of the niosomal formulation in the process of drug delivery.
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| Keyword:
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niosomes, vesicles, liposomes, pro-niosomes
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.397
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| Download:
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