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Development and Evaluation of Orodispersible Film Loaded with Ibuprofen Nanoparticles
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| Author:
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VISHAL B RAWAL, AFRASIM MOIN, SUBHAM JAIN N, AMIT B PATIL, MEENAKSHI S, SIDDARAMAIAH, NITHIN K S, D V GOWDA
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| Abstract:
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The aim of the present study was to formulate orodispersible film containing Ibuprofen nanoparticles and to promote the dissolution rate of Ibuprofen. IB loaded nanosuspension was prepared by high-pressure homogenization and then transformed into ODF containing IB nanoparticles by mixing with hydroxypropyl methylcellulose solution containing badam gum and PEG-400 followed by film casting and drying. Due to high-pressure homogenization, collisions between the drug particles and the impact of the shear force responsible for converting large drug particles into nanoparticles. All the prepared ODFs were evaluated for their disintegration time, the thickness of the film, in vitro testing to study drug release kinetic and were stored at room temperature to study the stability profile. Some selected ODFs were chosen for Scanning Electron Microscopy (SEM), XRD, and particle size analysis. ODF was disintegrated in water within 28 sec containing reconstituted nanosuspension with a particle size of 246.9 nm, showing a better redispersibility of the ODFs containing IB nanoparticles. SEM photographs showed differences in the morphologies of IB nanosuspensions had a granular shape and while well-dispersed IB nanoparticles in the films. ODFs contain IB was in the amorphous state confirmed by XRD studies. From the results obtained, F5 was selected as the optimized formulation with the drug content of 99.89 ± 1.6 %. In-vitro release study of F5 showed an optimum drug release of 92% in deionized water. Stability studies showed that the optimized ODFs were stable when stored at room temperature. From the above study, it was concluded that the prepared orodispersible film containing IB loaded nanoparticles was suitable to enhance the solubility and delivery of IB.
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| Keyword:
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Orodispersible film, Ibuprofen, Nanoparticles, High-pressure homogenization, Nanosuspension
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.401
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| Download:
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