|
Rutin trihydrate loaded liposomal gel formulation and characterization
|
|
| Author:
|
DIVYANSHI SHARMA, SUKIRTI UPADHYAY, PRASHANT UPADHYAY
|
| Abstract:
|
In this research paper, liposomes were prepared as drug carriers to raising the delivery of an antioxidant Rutin trihydrate for dermal administration. Prepared liposomes were done using 32 factorial designs by thin film hydration method and then were characterized for their physiochemical properties (particle size, polydispersity index, zeta potential and morphology).Optimization was accomplished by altering the lipid to cholesterol ratio and keeping the definite amount of drug constant. The formulation and process parameters were optimized to attain multilamellar liposomes with similar size and accurate entrapment. Entrapment efficiency for the optimized batch gave 90%. Liposomal Gels were prepared by using Carbopol 940 as the gelling agent. Prepared liposomal gels release profile for in-vitro and in-vivo compared with conventional gel formulations. The liposomal gel present prolonged drug release up to 11h. The safety of liposomal gels was ensured by conducting skin irritation studies on albino Wistar rats.
|
| Keyword:
|
Gels; Liposomes; Rutin trihydrate.
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2021.13.01.345
|
| Download:
|
Request For Article
|
|
|