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Preoperative adjuvant gabapentin with dexamethasone compared to dexamethasone alone for postoperative analgesia in cholecystectomy
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| Author:
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MRS ZAINAB NAJIM ABDUL-NABI (MSC), DR. ASIA ABDULLAH (PHD), DR.ALI GALIB MOHAMMED REDHA
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| Abstract:
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Objective: Severe postsurgical pains cause long-lasting hospital stay and are also thought to be a risk factor for the development of chronic pain. This study aimed at investigating the effect of preoperative adjuvant gabapentin with dexamethasone for postoperative analgesia in cholecystectomy compared to dexamethasone alone or compared to placebo treatment.
Methods: This study done during the period from January 2019 to May 2019. 60 patients (17-67 years old), scheduled for laparoscopic cholecystectomy, were allocated randomly into three groups, the first group (GD) administered oral gabapentin 600 mg, about one hour before surgery then 8 mg dexamethasone intravenously just before induction. The second group (D) administered only intravenous dexamethasone 8mg and the third group (C) considered as control, administered placebo treatment, which is same looking as treatment. All patients trained for the pain visual analogue scale (VAS) (zero for “no pain” and 10 for “worst pain”) for measurement of pain.
Findings: All groups in this study were similar concerning age, gender (male: female), height and body weight. The mean systolic and diastolic blood pressure and also heart rate were not different among the groups in any of the measured times (2h, 6h, 12h and 24h postoperatively). Meanwhile, there were statistical significant difference in oxygen pressure (p= 0.0091and p= 0.0200) after 2h and 6h from the surgery, respectively. Lower value of (VAS) found in (GD) group compared to (D) and (C) groups. The frequency of nausea and vomiting and the Tramadol and paracetamol consumption during 24h postoperatively was significantly lower in (GD) and (D) groups compared to group (C).
Conclusion: Gabapentin combination with dexamethasone causes significant reduction in the requirement of opioid postoperatively, reduction of postoperative pain and reduction of postoperative nausea and vomiting compared to the control placebo treatment.
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| Keyword:
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Gabapentin, Dexamethasone, laparoscopic cholecystectomy and postoperative analgesia.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.415
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| Download:
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