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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Updates on Synthesis and Biological Activities of Quinoline Derivatives: A Review

Author: SHIVALI MISHRA, SALAHUDDIN, RAJNISH KUMAR, AVIJIT MAJUMDER, AJAY KUMAR, CHANCHAL SINGH, DEVLEENA TIGLANI
Abstract: Quinoline is a versatile nucleus that belongs to the organic heterocyclic chemistry. It is containing a nitrogen atom in its skeleton hence, an alkaloid in nature was firstly introduced as Leukol by Friedlieb Ferdinand Runge (1834) which is synthesized by anilines which are the basic constructors for the nucleus generation process using different reagents such as CuCN, Boron trifluoride etherate [BF3.OEt2], Ytterbium (III) triflate [Yb (OTf)3], [W(CO)5(THF)], Benzotriazoleiminium salts, Tungsten vinylidene complex, [RuCl3.nH2O/3PPh3] and LiCl in common name reactions which are: Camps, Combes, Conard-Limpach, Doebner, Doebner-Von Miller, Friedlander, Skraup and Pfitzinger. Quinoline was also introduced from the field of phytochemistry as a part of the synthesis of various chemicals that have medicinal plants' chemical constituents like Quinine, Balaquine, Cusparine, Galipine, Echinopsine, Mefloquine, Pamaquine, Amodiaquine, etc. On other hand, quinolines also provide frameworks for industrial applications such as quinoline-based dyes such as ethyl red iodide and pinacyanol have been used since the 19th century. Photovoltaic cells and organic light-emitting diodes (OLEDs), along with solvents for resins and terpenes. The article aims at highlighting the different approaches for the synthesis of quinoline. Here, in this review, we discussed conventional and catalyst based approaches along with their reaction mechanism. Also, this review focuses on biologically active compounds which may be beneficial for further research and development of the quinoline ring system.
Keyword: Quinoline, Friedlander, Doebner, Echinopsine, Amodiaquine, Cusparine.
DOI: https://doi.org/10.31838/ijpr/2021.13.01.472
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