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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Core-Shell Nanoparticles Epigallocatechin-3-Gallate and Chitosan/Hyaluronic-Acid as a Socket Preservation for Dental Implant

Author: MARTINING SHOFFA PUSPITANINGRUM, RIFQAH ANANDA MAPPANANRANG, ALEXANDER PATERA NUGRAHA
Abstract: Background: Socket is clinical manifestation of post tooth-extraction in vertical and horizontal defect of alveolar bone which influence implant failure. Socket preservation using bone-graft is therapy which is required for successful implant. However, anti-inflammatory agent biomaterials are needed to relieve inflammation of the injury. Epigallocatechin-3-gallate (EGCG) is the most polyphenol compound in green tea (Camellia sinensis) which potentially as an antioxidant, anti-inflammatory, and osteoinductive. Chitosan/Hyaluronic-acid (CS/HA) is a combination of biocompatible crustacean shells based polymer as seafood waste which commonly found in Indonesia. Core-shell is an encapsulation method to increase stability and resistance of bioactive materials, increasing drug-delivery. Purpose: To describe the potential of core-shell nanoparticle EGCG-CS/HA as socket preservation material for dental implants. Discussion: Socket occurs by inflammatory response to post-extraction stimulates RANKL which activate osteoclast and lead to alveolar resorption. Post-extraction socket may complicate stomatognathic system rehabilitation by using dental implants. EGCG may induce BMP-2 and growth-factor which triggers osteogenesis, and inhibit osteoclast maturation anti-inflammatory pathway. CS is cationic polymer which is mucoadhesive, good physical stability, and biodegradable as capsule layer which controls release of bioactive compound. HA is an anionic glycosaminoglycan compound as drug release control which is non-immunogenic, biocompatible, and high viscoelastic. CS/HA are stable and can decrease secretion of pro-inflammatory cytokines (TNFa and IL-1ß). Core-shell nanoparticle EGCG-CS/HA synthesized by cross-linking method and efficiency encapsulation as socket preservation for implant which has antioxidant activity, inhibit osteoclastogenesis, and osteoinductive. Conclusion: Core-shell nanoparticles EGCG-CS/HA may be a biocompatible material which potential as socket preservation for dental implant.
Keyword: Core-shell nanoparticles, epigallocatechin-3-gallate, chitosan/hyaluronic-acid, socket preservation, dental implant.
DOI: https://doi.org/10.31838/ijpr/2021.13.01.544
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