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Herbal Approach and Its Molecular Hypothesis for the Management of Convulsant Induced Depression as Comorbidity: A Critical Review
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| Author:
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SUNITI CHAND, AVIJIT MAZUMDER, SAUMYA DAS, ANAMIKA SHARMA, ANKIT SHARMA, LALIT KUMAR, ROHITASH RATHOUR
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| Abstract:
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Epilepsy is a psychiatric chronic disease characterised via the repeatedly occurrence of epileptic seizures that are episodic and unpredictable. It is often related to brain disorders that contribute to many behavioural comorbidities, such as depressive disorders (DDs), Parkinson. There is a high prevalence of depressive disorder in epileptic patients. A population-based research has found that 29% of epileptic patients suffer from depression, As compared to 8.7% of healthy individuals. A recent research has also shown that a history of depression is associated with a 4 to 6 times higher risk of epilepsy development. Epileptic induced depression remains fragile. It is largely unclear how epilepsy affects the neuronal functions of depressants in the brain. Among the scores of molecules extensively expressed by depression induced via epilepsy, inflammatory cytokine, (IL-1ß), (IL-6), (TNF-a) are found to demonstrate a very significant induction. Controlled trials are urgently required due to inadequate evidence on pharmacological antidepressant management in epileptics. Epilepsy induced depression significantly limits the living. To enhance the quality of life of patients, treatment for epilepsy induced depression is therefore extremely necessary. To date, multiple phytochemicals, herbal formulations and plant extraction is able to manage comorbidity between epilepsy and depression due to their potential phytoconstituent hitting directly to the responsible molecular target. And this can be a great alternative or translational therapy that can prevent the development and worsening of comorbidity between epilepsy and depression.
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| Keyword:
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Epilepsy, Depression, Inflammatory cytokine, (IL-1ß), (IL-6)
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.049
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| Download:
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