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The Effect of Nutritional Supplement of Dried Figs on Renal Toxicity Induced by Ochratoxin (A) in Experimental Animals
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| Author:
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REEM ALAZRAGI
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| Abstract:
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Ochratoxin (A) is a fungal toxin that affects the kidneys, causing kidney failure. The kidney is the important
target organ of this mycotoxin. This study aims to determine the efficiency of dietary fortification with dried
figs as a rich source of antioxidants against renal toxicity induced by toxic fungicide. Forty white rats were
used, divided into 4 groups: (1) the control group, (2) the group treated with ochratoxin (A), (3) a group fed
by meals fortified with dried figs only, (4) a group that fed meals containing ochratoxin (A) and supported by
dried figs. Some measurements were made that included renal function, antioxidant enzymes in the renal
tissue, DNA fragmentation test, and histopathological kidney dissection test. A significant decrease in body
weight, kidney weight, and relative weight was observed in the group treated with ochratoxin (A), as well as an
increase in the level of creatinine, urea, sodium and potassium in the blood. Histopathological and
histopathological changes appeared as the renal tissue lost its normal shape with the appearance of DNA
cracking. As for the group that fed only the dried figs, their results were close to the control group, whereas
in the group fed on the dried figs with the ochratoxin (a), the severity of the pathological changes, whether
related to renal function or enzymatic stress enzymes in the renal tissue as well as the pathological dissection
of the kidneys, decreased. And DNA cracking. The results indicate that the ochratoxin (A) causes pathological
changes in the kidney tissue that may lead to kidney failure, and that the nutritional support of dried figs in the
meals containing the ochratoxin (A) has a protective effect, as the damage caused by the toxicity of the
ochratoxin (A) on the kidney tissue has been reduced.
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| Keyword:
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fig, ochratoxin (A), kidney and renal toxicity
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.111
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| Download:
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