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Evaluation of Antidepressant Activity of Methanol and Petroleum Ether Extracts of Daucus Carota Ssp. Sativus Var. Atrorubens Alef. (Purple Carrot) Roots in Experimental Animals
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| Author:
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B.KRUPAVARAM , S.LASHINNA, HANISH SINGH JC, BVS.LAKSHMI, SHASHIDHARAN MENON, H.JAASMINERJIIT KA
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| Abstract:
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In traditional system Daucus carota ssp. is useful in treating various ailments. The objective of the study was to
preliminary phytochemical screening and evaluate antidepressant effect of methanolic and petroleum ether
extract of Daucus carota ssp. (purple carrot) roots in different behavioural models such as forced swimming
test (FST), tail suspension test (TST) and open field test (OFT) in animal models. Preliminary phytochemical
screening of methanol extract showed the presence of alkaloids, flavonoids, glycosides, phenols, proteins,
amino acids, volatile oils and steroids. Petroleum ether extract showed the presence of alkaloids, flavonoids,
glycosides proteins, amino acids, and volatile oils. Both the extracts (200 and 400 mg/kg) of were administered
via oral route and studied behavioural studies by FST, TST and OFT models. In FST and TST, both the extracts
were highly significant (p<0.001) by reducing the immobility duration in rats and mice respectively, almost
comparable to standard drug (Fluoxetine 20mg/kg). Methanol extract of 200 mg/kg, showed less significant
(p<0.05) in frequency of rearing activity compared to petroleum ether extract (400 mg/kg) in open field test.
Methanol extract of 200 mg/kg showed significant (p<0.01) in frequency of lines crossing compared to standard
drug, and frequency of head dippings in both the extracts showed highly significant (p<0.001) than Fluoxetine
20mg/kg. These results demonstrated that Daucus carota L. possesses antidepressant like effect in behavioural
model. The present study warrants further investigations on the mechanism of action of purple carrot in the
CNS, in both methanolic and petroleum ether extracts.
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| Keyword:
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Antidepressant, Daucus carota ssp. sativus var. atrorubens Alef., Forced swimming test (FST), Tail suspension test (TST), Open field test (OFT)
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.127
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| Download:
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