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Construction and analysis of the proteins interaction network for the four types of leukemia
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| Author:
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ORAS N. HAMAD, MOHD S. SHAMSIR, S. I. AMRAN , AHMED Q. ABD-ALHASAN
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| Abstract:
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Among the four types of leukaemia, there are several genes, which are topologically linked that interact in the
network and have functions in leukaemia. It has become an important practice and is common to find
biological pathways and cellular mechanisms that are associated with disease-related proteins and newly
discovered genes. The main goal of this study was to create an interaction network between the four types of
leukaemia and study the associated molecular function. In this study, we created the first protein interaction
network for four humans of leukaemia types that consists of 101 nodes with 807 interactions. Gene ontology
analysis found various functional clusters, which are perhaps implicated in the interaction of leukaemia types.
These contain response to chemical stimuli, negative regulation of the cellular processes, glyoxylate cycle,
antigen processing and presentation, and G1/S phases transition from the mitotic cell cycle. The PPI network
appeared as an extremely interconnected network, and we detected the following candidate proteins:
BCL2L11-BCL2L1, JAK2-STAT5B, JAK2-STAT5A, BCL2L1-TP53, MTOR-RPS6KB1, IDH1-IDH2, HLA-B-HLAA, and SKP2-CDKN1B that may have a significant function in the interaction of leukaemia types. The results
also showed that AKT1 and CTNNB1 had the highest degree and highest BC node in the PPI network.
Therefore, we can consider it as a drug target for future studies in diagnosis or medical treatment. The
statistically significant results from a Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis
demonstrated 101 pathways with 45 genes related to cancer with a kappa threshold of 1.00. This study
provides a map that will help future researchers in the field of molecular mechanisms, and will simplify the
biological interpretation of interactions between leukaemia types.
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| Keyword:
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AML; ALL; CML; CLL; Leukemia; Protein-protein interactions
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.179
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| Download:
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