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Formulation Development, Optimization and Evaluation of Glipizide Floating Microspheres
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| Author:
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RAVI DAVE, RIDDHI TRIVEDI, JAYVADAN PATEL
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| Abstract:
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The purpose of this study is to produce floating microspheres of glipizide. The hypothesis was that it would
remain in the intestine for a long time and increase the sensitivity of the medication to its absorption position.
Floating glipizide filled microphones were prepared using an emulsion solvent evaporation process. Various
polymers have been developed to calculate floating sizes, density, compressibility index, homeland ratio,
repository angle, drug load and enclosure consistency Eudragit S 100 and Kollidone SR, cellulose acetate,
Acrycoat S 100, Methocel K4M, Methocel K15M and Methocel K100M. Release tests with in vitro phosphate
buffer pH (7.4) were performed at 37 ff for a full 12-hour f. Samples have been removed at various periods and
a total number of medication releases have been estimated. The percentage of drug release has been recorded
in both formulations. The formulation k1 containing Kollidone SR was considered to be appropriate in all its
formulations because it was increased to 94.75 per cent at the end of 12 hours. The rate of swelling of highviscosity particles was assumed to be lent in relation to Kollidone SR.
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| Keyword:
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Glipizide, Floating Microspheres, formulation development
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.703
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| Download:
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