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Molecular genetics involved in the pathogenesis of colorectal cancer: a review
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| Author:
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, SRI RASHMY MADATHIL, POORNIMA KANNAPPAN, SRIDHAR MUTHUSAMI, PERUMALSAMY MUNEESWARI
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| Abstract:
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Colorectal Cancer, (CRC) is the third most frequently diagnosed neoplasm globally and found to be a major cause of mortality in terms of gastrointestinal malignancy. Risk factors associated with CRC development include hereditary factors, age, lifestyle, defective alimentary habit and chronic gastric inflammation. Molecular genetics of CRC is highly heterogeneous and involves accumulation of genetic and epigenetic mutation. Genetic variants of CRC include Chromosomal Instability (CIN), Microsatellite Instability (MSI) and CpG Island Methylation Phenotype (CIMP) involving crosstalk between various molecular signaling pathways like Wnt/ß-catenin, PI3K/AKT pathway, NF-kB pathway etc and a consortium of genes and proteins contributing in whole process of neoplasm onset and progression. An understanding of genetic mechanism will help in developing novel biomarkers for better diagnosis and effective treatment strategies by targeting genes and molecular signaling pathways involved in evolution of carcinoma. Upgrading molecular genetics will help in developing novel approaches in targeted therapy employing monoclonal antibodies. Following review provides a basic overview of genetic mechanism involved in colorectal carcinoma.
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| Keyword:
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Colorectal cancer, Genetics, Signaling pathways, Genes.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.252
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| Download:
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Request For Article
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