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Designing of luliconazole (lcz) in aloe vera gel loaded solid lipid nanoparticle and its evaluation
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| Author:
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MUKESH KUMAR, PRASHANT KUMAR, NIDHI SINGH, PRASANJIT PAUL, DR.LUBHAN SINGH, DR.SOKINDRA KUMAR, DR.ANOOP KUMAR
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| Abstract:
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The solid lipid nanoparticle of an anti-fungal drug is prepared in the present study and the drug luliconazole
loaded nanoparticles have been poured into the matrix of aloe vera gel to improve drug penetration through
the skin. Luliconazole solid lipid nanoparticles (SLN-LCZ) are formulated via the process of solvent
emulsification to ensure improved trapping efficiency and continuous drug delivery. Aloe vera gel
demonstrated with medicinal capabilities and excellent care as per WHO "Portal of health products & essential
medicine". Compared to other standard anti-fungal creams, the in vitro evaluation of SLN-LCZ gel showed
brilliant spreadability, adhesiveness & easy application, as well as a better in vitro drug release profile. Gel
formulation stability was also found to be stable at low temperatures of up to 2°C as well as high temperatures
of up to 40°C. Finally, the SLN-LCZ-containing aloe vera gel formulation for topical drug delivery proves to be
a promising nano carrier for the delivery of drugs targeting infectious skin diseases. The formulations have
been shown to be effective, consistent with increased drug penetration to the skin achieved.
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| Keyword:
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Anti-fungal, Luliconazole (LCZ), Bioavailability, Solid Lipid nanoparticles, Aloe Vera gel, Solvent emulsification method.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.290
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| Download:
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