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Evaluation of the therapeutic effect of nano-gold Bauhinia-variegata leaves extract against breast cancer- induced rats
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| Author:
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, ABEER HAMED ABDEL-HALIM, AMAL ABDEL AZEEM FYIAD, WAEL MAHMOUD ABOULTHANA, AHMED MAHMOUD YOUSSEF, NEVIEN MAHMOUD SABRY, WAGDY KHALIL BASSALY KHALIL, MAMDOUH MOAWAD ALI
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| Abstract:
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Breast cancer is the most prevalent cancer amongst females worldwide. Nanotechnology emerged as
important technique to deliver therapy to the place of action and increased its bioavailability. Our task is to
investigate the therapeutic efficiency of nano gold Bauhinia variegata methanolic leaves extract against breast
cancer in rats. The study conducted on 24 albino Western rats divided into 4 groups, 6 rats each as follows:
control group, N-methyl-N-nitrosourea (MNU) group, where rats were injected intraperitoneally (i.p.) with
two doses of MNU (50 mg/kg b.w.) at week seven and week sixteen of age, nano gold extract treated group,
where rats administered B. variegata gold nano-extract orally at a dose of 2.58 ml/kg and MNU-nano gold
extract treated group, where rats were injected as in MNU group and then they were treated with nano gold
extract for four weeks starting from the week twenty-five of age. MNU injection caused elevation of liver and
kidney functions, TP, lipid peroxidation, cyclooxygenase-2 (COX-2), vascular endothelial growth factor
(VEGF), DNA damage rate and proinflammatory cytokines expression with a decrement in SOD, CAT
activities, GSH level and caspase-3 expression. Treatment breast cancer-induced rats with nano gold B.
variegata extract ameliorated the apoptosis and antioxidant defense system and decreased inflammation,
angiogenesis and DNA damage rate. It can be concluded that nano gold B. variegata extract exerted its
chemotherapeutic effect against breast cancer-induced rats through reducing inflammation, angiogenesis and
DNA damage associated with increasing apoptosis and antioxidant defense activity due to its high polyphenolic
contents.
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| Keyword:
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Breast Cancer, Medicinal Plants, Inflammation, Angiogenesis, Apoptosis.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.336
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| Download:
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