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Correlation of Antenatal Depression Among the Iron And s-25(OH)D Deficient Pregnant Women: An Observational Study in A South Indian Population
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| Author:
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ROOPA SATYANARAYAN BASUTKAR, THOMAS EIPE, DIVYA P, SIVASANKARAN P
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| Abstract:
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Background: Antenatal depression affects one in five women globally. The prevalence of antenatal depression symptoms is very prominent among the s-25(OH)D and iron deficient pregnant women.
Objective: To elucidate the correlation between s-25(OH)D, hematological parameters and antenatal depression using Edinburgh Postnatal Depression Scale (EPDS).
Methods: A prospective, observational study was conducted in iron and s-25(OH)D deficient pregnant women who visited antenatal care at Government Headquarters Hospital, Udhagamandalam. Pregnant women at their 26-28 weeks of gestation were screened and those with hemoglobin (Hb) < 11.0g/dL; s-25(OH)D levels < 30ng/ml were enrolled to complete the EPDS.
Results: Complete datasets were available on 120 subjects. Descriptive analysis was performed for the demographic characteristics. Multiple linear regression and Pearson correlation was used to determine the strength of association between s-25(OH)D, hematological parameters and EPDS scores. For the 120 subjects recruited, the mean s-25(OH)D was 17.15±6.01ng/mL and the mean hemoglobin was 9.46±0.87g/dL. The mean EPDS was 9.37±4.83, and 42 (35%) women had an EPDS =12, suggestive of clinical depression. A significant, inverse linear relationship was found between EPDS scores and the concentration of s-25(OH)D (r = -0.294, n = 120, p = 0.001) and for every 1-unit increase in s-25(OH)D, the average decrease in EPDS score was .236 (95% CI: -0.377, -0.96; p = 0.001).
Conclusion: Our findings suggested that in this population of pregnant women, the low s-25(OH)D levels were significantly correlated with antenatal depressive symptoms.
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| Keyword:
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Vitamin D deficiency, Iron deficiency anemia, Antenatal depression, Pregnancy, Edinburgh Postnatal Depression Scale
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.291
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| Download:
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