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Assessment of COX-II Inhibitor and Immunosuppressant Drug Combination as a Therapy in Rheumatoid Arthritis
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UPLOADED BY-ADMIN, SURYAWANSHI VISHAL BAPURAO, CHAWARE VITTHAL J, BIYANI KAILASH .R
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| Abstract:
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Cyclophosphamide is a disease modifying anti-rheumatic drug that is widely used for the treatment of rheumatoid arthritis.
Etoricoxib is a non-steroidal anti-inflammatory drug which is frequently used as adjuvant therapy for symptomatic
alleviation of rheumatoid arthritis. In this study, we have evaluated the potential influence of etoricoxib on the disease
modifying anti-rheumatic properties of cyclophosphamide using the adjuvant-induced arthritis model. Rats were immunized
with adjuvant for the induction of arthritis and treated with cyclophosphamide (10 mg/kg p.o.), etoricoxib (0.60 mg/kg p.o.)
and a combination of both drugs every day. Treatment started from the day of arthritis induction until day 21. An arthritic
index, paw volume was used to compare the severity of arthritis between different treatments. In addition, haematological
test like WBC, RBC, Hb count; serological test like rheumatoid factor, C.R.P. test, Histopathological study and radiological
deterioration were evaluated. The result indicates that Cyclophosphamide and etoricoxib protected rats against arthritic
lesions, body weight changes and haematological perturbations induced by FCA, it also minimises paw oedema and arthritic
score. Radiographic analysis also confirms the potent anti arthritic effect of combination therapy. Histopathology revealed
significant reduction in necrosis of bone, connective tissue proliferation, cellular infiltration and oedema. It is concluded that
etoricoxib significantly improved the disease modifying anti- rheumatic profile of cyclophosphamide.
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Cyclophosphamide, Etoricoxib, Rheumatoid arthritis, Adjuvant induced arthritis.
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