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Effect of Trigonella foenum-graecum Seed Powder in High Fat-High Fructose Diet-Induced Prediabetes in Rats
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| Author:
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R.PADMAVATHI, S.KADDARE, MOHAMMED ABDUL SAMAD, A.LALITHA DEVI, Y.SREEHARI
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| Abstract:
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Prediabetes is an intermediate glycemic state which is above normal and below glycemic threshold for diagnosis of type-2 diabetes. People with prediabetes are at high risk of developing Type-2 diabetes as well as 50% increase in heart diseases and stroke. Treatment option other than metformin is associated with adverse effects and limits their use in prediabetes. The present study aimed to evaluate the beneficial effects of Trigonella foenum-graecum seed powder in High Fat-High Fructose (HFHF)-diet-induced prediabetes in rats. Wistar rats of either sex were divided into three groups. Group 1 received standard pellet diet and 1% CMC, Group 2 received HFHF-diet for 6-weeks and Group 3 received HFHF diet for 6 weeks followed by Trigonella foenum-graecum for 28 days. Body weight, Fasting Blood Glucose (FBG), lipid and liver profile and Oral Glucose Tolerance Test (OGTT) was carried at end of the study. HFHF-diet for six weeks has significantly increased fasting blood glucose, triglyceride levels, and increased glucose tolerance during OGTT in Groups II and III animals. Trigonella foenum-graecum treatment resulted in a substantial reduction in FBG, lipids, and liver parameters, as well as an improvement in high density lipoproteins. During the OGTT, a reduction in glucose tolerance was found. Trigonella foenum-graecum seed powder, used as a supplement in dietary improvement, has been shown to slow the progression of prediabetes to diabetes and boost overall prediabetic conditions.
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| Keyword:
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Prediabetes, Trigonella foenum-graecum, FBD, OGTT, Lipids.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.452
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| Download:
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