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Correlation of Bacterial Biofilm Grade with Allergy in Chronic Rhinosinusitis Without Nasal Polyp
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| Author:
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TETI MADIADIPOERA, LINA LASMININGRUM, SINTA SARI RATUNANDA, IFIQ BUDIYAN NAZAR, EDWINA DRIYAN ANINDYA
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| Abstract:
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Introduction: Chronic rhinosinusitis (CRS) is a common health problem affecting the population of the world including Indonesia, especially in Dr. Hasan Sadikin Hospital, West Java, Indonesia. The proposed pathogenesis of CRS is thought to be multifactorial, including the presence of microorganisms and allergy. Both clinically and immunobiologically, chronic rhinosinusitis without nasal polyp (CRSsNP) is chronic inflammation of nasal and sinus mucosa with showing the abundant eosinophils correlated to allergic status which makes the Skin Prick Test (SPT) become essential test in contributing CRSsNP. Objectives: To evaluate allergy factor that may be associated with bacterial biofilm formation in CRSsNP. Materials and Methods: A cross-sectional design, analytic observational prospective study. Fifty patients with chronic sinusitis without nasal polyp were enrolled from September 2019-May 2020. Samples were taken to evaluate for biofilm formation using a Tissue Culture Plate/TCP Method and to evaluate for allergy factor by SPT using Alk-Abello. Data were analyzed using Chi-Square test. Result: Biofilm formation was found in 25/50 (50%) CRSsNP patients. Of 25 patients found biofilm formation, 15 patients were positive in SPT and 10 patients were negative, with details 8 patients showed none form the biofilm, 4 patients mild, 1 patient were moderate and 2 patients were strong implication, with Staphylococcus aureus comprised most of the samples. Bacterial biofilm formation was not significantly associated with allergy (p>0,05). Conclusion: The probability of bacterial biofilm formation is independent of many clinical factors, one of which is allergy factor, considered to be risk factors for CRS.
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| Keyword:
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Bacterial biofilm, Chronic Rhinosinusitis without Nasal Polyp, Skin prick test.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.407
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| Download:
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