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Design Optimization and Evaluation of Cisplatin loaded PLGA Nanoparticles using Response Surface Methodology
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| Author:
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C SUBBA PARAMESWARI, S UMADEVI
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| Abstract:
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The research study aims to execute the possibility of Cisplatin (C) loaded with poly lactide-co-glycolide - PLGA nanoparticles to be controlled drug releasing systems. The nanoparticles are one of the unique and new drug vehicle that prepared to use as the controlled release systems of an anticancer drug. Double Emulsion Solvent Evaporation technique was adopted to fabricate carriers C–PLGA nanoparticles and they were used for loading cisplatin. The formulation optimization was done using CCRD-RSM. The prepared nanoparticles containing drug encapsulated with efficient polymer acts as targeting systems to the specific site. By using FT- IR spectroscopy, the compatibility between various used components of the design was evident, no major interaction occurred between the drug and polymers and the SEM determined the spherical shape of the particles. The sizes of prepared polymeric nanoparticles of the C–PLGA, were between 108 and 246 nm, as determined by a Zetasizer 3000 HSA. The nanoparticles are characterized for efficiency of drug encapsulation, capacity of drug loading and drug relase of C–PLGA respectively. The research findings disclosed that the strong cross linked C–PLGA polymeric nanoparticles can be a absolute polymeric carrier for effective delivery of Cisplatinin controlled rate. The investigative findings obtained from experiments disclosed that polymeric nanoparticles fabricated and optimized in this research work.
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| Keyword:
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Cisplatin, Polymeric nanoparticles, poly lactide co- glycolic acid, Response Surface Methodology.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.392
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| Download:
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