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To evaluate the effect of Estrogen receptor gene polymorphisms are associated with Lipid level among post-menopausal women
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| Author:
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FARUQUE AHMED, PALLAVI ANAND, PAWAN A.KULKARNI, ANIL KUMAR
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| Abstract:
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Introduction: Altered lipid profile due to Estrogen deficiency could lead to increase the prevalence of the metabolic syndrome in postmenopausal women compared with premenopausal women, and this postmenopausal worsening of the metabolic profile may contribute to the future risk of CVD.
Material and Methods: The present study was conducted in the Department of Biochemistry with the collaboration of Department of OBG & GYNE. Comprising 126 healthy age and sex-matched subjects selected from the OPD of Rama Medical College & Hospital. Kanpur. U.P. Female subjects above the age of 18 with no confounding factors as mentioned in exclusion criteria were recruited as controls. Women who have naturally attained post-menopause stage with no confounding factors were recruited as study subjects.
Result: Frequency distribution of Estrogen receptor –a polymorphism of PvuII in Premenopausal were CT 43.24% genotype and followed by CC 36.04% and least genotype was TT 20.72%. Furthermore, Postmenopausal Women PvuII was more CT 45.22% genotype and followed by CC 34.78% and least was TT 20% in table. Frequency distribution of Estrogen receptor –a polymorphism of Xbal in Premenopausal were AG 54.95% genotype and followed by AA 25.23% and least genotype was GG 19.82%. Furthermore, Postmenopausal Women Xbal was more AG 55.65% genotype and followed by AA 25.22% and least was GG 19.13%.
Conclusion: Our finds showed no association between the PvuII polymorphism and serum concentration of TL, T-chol, LDL, HDL, and TG in post-menopausal woman. Nevertheless, XbaI polymorphisms showed a strong association between with higher serum levels of TL and TG, which seems to be also age and BMI dependent. Our results suggest that the XbaI polymorphism effects over the lipid profile in post-menopausal women may be related to the age.
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| Keyword:
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Lipid Profile, Menopause, Osteoporosis, Postmenopausal women.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.451
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| Download:
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Request For Article
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